Pure Stem Nasal Spray Kit

Integrated with Online Consultations.
A more accessible option with the Pure Stem Nasal Spray Kit.

The approach to beauty and wellness enters a new stage.

Our proprietary freeze-drying technology locks high-quality ingredients into vials, keeping them fresh until the moment of use. Conveniently, no special equipment is necessary.

Additionally, seamless coordination with telehealth allows you to consult a doctor from the comfort of your home and conveniently begin high-quality care using the prescribed kit. This brings advanced self-care closer and offers more freedom. Embrace the future of conditioning now with the Pure Stem Nasal Spray Kit.

• Why Nasal Delivery?
• Recommended For
• Pure Stem Nasal Spray Kit: 5 Key Features
• Product Lineup
• How to Use
• For Medical Institutions Considering Introduction

Why Nasal Delivery?

Characteristics of the Nasal Mucosa:
Why is Nasal Administration Attracting Attention?

Inside our nasal passages, the mucosa lining the airways we breathe through daily possesses unique physiological characteristics not found in other administration routes. In recent years, research has progressed on delivery systems utilizing these features to efficiently deliver components.

1. Rich Vascular Network and Excellent "Absorption"

Beneath the inner walls of the nasal cavity, particularly in areas like the inferior turbinate, an extremely fine network of capillaries is densely spread like a net. The surface area of the mucosa itself is also large, and it has a relatively thin structure.

Because of this, it is believed that components (such as those with smaller molecular weights) administered into the nasal cavity are efficiently absorbed through this abundant vascular network and directly enter the systemic bloodstream. This also connects to the advantage of being less susceptible to the "first-pass effect" (metabolism in the liver after absorption) compared to oral medications, potentially increasing the bioavailability (the rate and extent to which a substance reaches systemic circulation).

2. Anatomical "Proximity" to the "Brain"

The area known as the "olfactory mucosa," located at the very top (roof) of the nasal cavity, is physically very close to the brain (particularly near the olfactory bulb and frontal lobe, areas related to memory and emotion).

Furthermore, and importantly, this olfactory mucosa contains nerve cells (olfactory nerves) responsible for detecting smells, and their nerve fibers extend directly into the brain (olfactory bulb). Normally, the brain has a powerful barrier called the Blood-Brain Barrier (BBB) that prevents many substances in the blood from entering the brain. However, numerous basic research studies have reported the possibility of pathways via the olfactory and trigeminal nerves distributed in the nasal cavity (the "Nose-to-Brain Delivery" route). Through these pathways, some components might bypass the BBB and directly enter the cerebrospinal fluid or brain tissue. This area is currently under active investigation.

[Summary]

Due to these characteristics of "excellent absorption" and "proximity to the brain," nasal administration (nasal spray) is considered a delivery method that (1) facilitates efficient systemic delivery of components and (2) holds potential for direct approach to the brain. As such, it is gathering significant attention for its possibilities in fields like pharmaceutical development, regenerative medicine, and self-care aimed at daily conditioning.

Benefits of Nasal Administration:

• Ease and Convenience: Unlike injections, it's generally painless, meets less resistance, and allows for easy self-administration.
• Non-invasiveness: Less burdensome on the body.
• Bioavailability: This route is considered to largely bypass first-pass metabolism in the liver.

The Unique Value of the Pure Stem Nasal Spray Kit:

• Utilizes high-quality, high-concentration freeze-dried ingredients (further details on the specific ingredients are available separately).
• Ingredients can be reconstituted when needed, ensuring freshness at the time of use.
• Allows selection of ingredients tailored to specific purposes.

Recommended For

For those seeking continuous care:

• Individuals who want to complement clinic treatments, such as IV drips, with at-home care.
• Those whose schedules make frequent clinic visits difficult.

For those prioritizing convenience:

• Individuals uncomfortable with injections.
• Those who want to incorporate care into their daily lives regardless of location (portability).

For those interested in new care methods:

• Individuals interested in the novel delivery system via the nasal route.
• Those who want to manage their wellness more proactively.

For those wanting to utilize telehealth:

• Individuals who want to receive online medical consultations, receive the product at home, and perform self-care.

Pure Stem Nasal Spray Kit: 5 Key Features

Choice of 5 High-Quality Ingredients:

• Allows selection of the optimal ingredient according to your purpose:
  Human Stem Cell Conditioned Media (Adipose-derived, Tooth Pulp-derived, Umbilical Cord-derived), Exosomes (from Umbilical Cord Blood), NMN.

Convenient Dedicated Kit for Portability:

• Compact size for easy carrying.
• User-friendly original nasal spray bottle (made in Japan).

Quality Preservation through Freeze-Drying:

• Maintains the activity of heat-sensitive components.
• Preservative-free.
• Fresh quality as it's reconstituted at the time of use.

Room Temperature Storage & Management (Before Reconstitution):

• Easy management as no special storage facilities are required.
• Suitable for clinic inventory management and shipping to patients (telehealth)[3].

Consideration for Safety:

• Rigorous safety testing of the raw ingredients (e.g., virus-free certification - see raw material documentation for details).
• Safety Data Sheet (SDS) available for the dedicated solvent (0.9% saline solution)[9-25].

Product Lineup

Usage manual

Preparation: Check Kit Contents

Reconstitution (Mixing the Solution):

1. Remove the cap and rubber stopper from the freeze-dried ingredient vial.
2. Open the dedicated solvent vial. Using the dropper integrated into the solvent vial cap, transfer the entire amount of the dedicated solvent into the freeze-dried ingredient vial.
3. Replace the rubber stopper on the ingredient vial and gently swirl or shake to mix until the powder is fully dissolved. Check to ensure it's completely dissolved.
4. Using the same dropper, carefully transfer the prepared solution into the empty nasal spray bottle. Your nasal spray is now ready.

Administration (Spraying):

1. Shake the nasal spray bottle well before each use.
2. Spray the specified number of times (as instructed by your doctor) into each nostril.
3. Tilt your head back for a short while after spraying to prevent the liquid from dripping out.

Storage:

• After reconstitution, the solution MUST be stored in the refrigerator.
• Since the solution is preservative-free, use it promptly (within 7 days).
• The nasal spray bottle is single-use only.
  Do not reuse it.

Instruction Manual

• Please refer to the enclosed instruction manual for detailed steps, illustrations, and precautions.

For Medical Institutions Considering Introduction

[The Benefits for Patients are Clear]

• Significant Improvement in Convenience:
  High-quality self-care* based on doctor's instructions becomes possible at home, greatly reducing the burden of clinic visits (time, cost, effort).
• Promotion of Continued Use:
  Patients can easily adhere to their care plan actively as they can continue care without disrupting their lifestyle.
• High Compatibility with Telehealth:
  Convenience is further enhanced as everything from consultation to product receipt can be completed at home.

[This Directly Translates into Benefits for Clinics Too]

• Improved Patient Satisfaction and Continuation Rates:
  High convenience increases patient satisfaction and willingness to continue care, contributing to building strong relationships with the clinic.
• Approaching New Patient Segments:
  Opportunities expand to offer your clinic's high-quality care to those who found visits difficult or live far away.
• Activation of Telehealth Services:
  The nasal spray kit is suitable for telehealth prescriptions, supporting the diversification of your clinic's service style.

The "Pure Stem™ Nasal Spray Kit," offers significant benefits to both patients and clinics. We are confident that this new form of care will help further enhance the service value of your clinic.

Please feel free to contact us for consultations regarding introduction, requests for detailed materials, etc.

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